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KMID : 0811720080120020079
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Korean Journal of Physiology & Pharmacology
2008 Volume.12 No. 2 p.79 ~ p.82
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Protective Effect of Decursinol on Mouse Models of Sepsis:Enhancement of Interleukin-10
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Jung Jun-Sub
Yan Ji-Jing
Song Dong-Keun
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Abstract
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The effects of decursinol on various models of sepsis were investigated. Intra-peritoneal pretreatment of mice with various doses of decursinol (1∼100 mg/kg) effectively suppressed lethality induced in three mouse models of experimental sepsis, i.e., lipopolysaccharide (LPS)/D-galactosamine (GalN), high-dose LPS (20 mg/kg), and cecal ligation and puncture (CLP). Intra-peritoneal pretreatment of mice with decursinol (50 mg/kg) markedly enhanced the LPS/GalN-induced increase of plasma interleukin-10 (IL-10) levels, without affecting plasma TNF-α , IL-6 and IL-12 levels. These results suggest that decursinol could be effective for prevention or treatment of sepsis.
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KEYWORD
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Decursinol, Experimental sepsis, Interleukin-10
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